376 papers
This chapter reviews computational strategies for exploring RNA conformational ensembles, highlighting current limitations in sampling and force-field accuracy while discussing case studies and emerging directions like machine learning and experimental integration to enhance predictive power.
This study demonstrates that small extracellular vesicles derived from the embryonic mouse cortex confer neuroprotection and restore neuronal function in aged models by delivering surface-bound BDNF to activate the CaMKIIα signaling axis, thereby stabilizing microtubules and enhancing synaptic plasticity.
This study reveals that the transcription factor FOXC1 drives ARHGAP36 expression to inhibit PKA and dysregulate the Hedgehog signaling pathway, a mechanism that, while promoting malignancy in murine models, paradoxically predicts improved five-year survival in human neuroblastoma patients.
This study reveals that spirochetal RNA polymerase possesses a diminished ability to melt promoters and a unique mechanism of -35 element disengagement, which are compensated by CarD and accompanied by unusually tight non-sequence-specific DNA binding, collectively highlighting the distinct regulatory and structural adaptations of transcription in spirochetes.
This study demonstrates that genotoxic stress-induced eight-exon skipping in the MDM2 proto-oncogene is governed by a distal regulatory element within the final exon, supporting an "Exon Regulon" model of coordinated splicing that offers new insights for developing cancer therapies targeting specific splice variants.
This study presents a novel, inducible, and reversible neuron-like model that mimics gradual SIRT6 depletion to recapitulate key molecular hallmarks of brain aging and neurodegeneration, enabling the distinction between physiological and pathological changes while identifying disrupted nucleocytoplasmic transport as a shared mechanism.
This study demonstrates that the H2A.Z R80C mutant suppresses the senescence-associated secretory phenotype (SASP) in human fibroblasts by destabilizing nucleosomes to reduce H3K27ac levels at SASP gene loci, independent of cell cycle regulation or H2A.Z depletion.
This study introduces a Compound Heterozygous Allele Conversion Reporter (CHACR) cell line to elucidate the mechanisms of Cas9-mediated allele conversion, demonstrating that targeted DNA damage can repair heterozygous mutations using the homologous allele as a template and that this efficiency can be enhanced by modulating DNA repair pathways.
This study reveals that *Komagataella phaffii* uniquely encodes two functional Pho4 transcription factors, Pho4(A) and Pho4(B), which exhibit partially overlapping yet distinct roles in regulating the response to phosphate starvation and alkaline stress.
Transcriptomic analyses of dermal tissue reveal that sharks exhibit significantly higher expression of four major DNA repair pathways compared to rays and skates, suggesting a potential evolutionary advantage in mitigating genotoxic damage from environmental pollutants and resisting cancer.
This manuscript, which originally investigated the role of estrogen in enhancing cardiac protection via extracellular vesicles from cardiac progenitor cells, has been withdrawn by the authors to incorporate additional data and undergo substantial revision prior to resubmission.
This study demonstrates that an allele-specific antisense oligonucleotide effectively clears mutant EFEMP1 transcripts and reverses disease-associated extracellular deposits and intracellular lipid accumulation in a patient-derived model of Doyne honeycomb retinal dystrophy, suggesting a promising therapeutic strategy for this incurable condition.
This study reveals that aneuploidy drives cancer progression and metastasis by inducing lysosomal dysfunction and CEBPB-mediated suppression of PARP1, which confers resistance to ROS-induced cell death and genotoxic stress.
This study demonstrates that age-related alterations in neuronal membrane lipid composition drive the formation of distinct -synuclein fibril polymorphisms with unique structural cores and enhanced pathogenicity, thereby linking membrane dynamics to the specific clinical phenotypes of synucleinopathies.
This paper introduces two training-free, inference-time conditioning strategies, Interpolate-Integrate and Replacement Guidance, for E(3)-equivariant flow-matching models to enable efficient, high-quality bioisosteric 3D ligand design without costly retraining.